Login

Join for Free!
119285 members
table of contents table of contents

Taken together, these data form a primary framework for understanding the evolution …


Biology Articles » Zoology » Mammalogy » Differential expression of WNT4 in testicular and ovarian development in a marsupial » Conclusion

Conclusion
- Differential expression of WNT4 in testicular and ovarian development in a marsupial

The two hypotheses for WNT4 action as an anti-testis gene [4] and as an important factor in testis development [7] are not mutually exclusive. Our data show that WNT4 is down-regulated for a brief period of time when the testis cords are first formed and the cell types of the testis determined, but then becomes up-regulated after day 10 post partum to control later testicular development. In the ovary, WNT4 remains strongly expressed in the gonad consistent with its role in inhibiting early testicular development and promoting later ovarian differentiation. It may also be important for the maintenance of germ cells in both females and males throughout development. Our data support the conclusion that WNT4 functions not only as an anti-testis gene during early mammalian development, but is also necessary for later ovarian and testicular function.

rating: 1.00 from 1 votes | updated on: 21 Jul 2008 | views: 5593 |

Rate article:







excellent!bad…