We thank James Campbell, John Manis, and Li Cai for helpfuldiscussions. D.Z. is supported by National Institutes of Health(NIH) Training Grant HL066987. H.L. was supported by NIH GrantsNS052200 and GM076084 and a research scholar grant from AmericanCancer Society.
Abbreviations: PI3K, phosphatidylinositol 3-kinase; PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate.
*To whom correspondence should be addressed. E-mail: [email protected]
Author contributions: H.R.L. designed research; D.Z., H.H.,H.J., Y.J., K.K.S., F.L., and J.Y. performed research; Y.L.,M.H., and L.S. contributed new reagents/analytic tools; D.Z.,H.H., H.J., Y.J., K.K.S., F.L., and H.R.L. analyzed data; andH.R.L. wrote the paper.
The authors declare no conflict of interest.
This paper was submitted directly (Track II) to the PNAS office.
© 2006 by The National Academy of Sciences of the USA