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This methylation study indicated that cyclin A1 is a potential tumor marker …
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- Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer
This study demonstrates the strong association between CCNA1 promoter hypermethylation and invasive HPV-associated CC indicates that this gene could serve as an effective molecular marker. Moreover, our finding, in comparison with previous reports, [13,14] also suggests that there is a possible molecular link between oncogenic HPVs, TP53 and CCNA1 promoter hypermethylation.
CC: cervical cancer, CCNA1: cyclin A1, SILs: squamous intraepithelial lesions, HPV: Human papillomavirus, WBC: white blood cell
The author(s) declare that they have no competing interests.
NK: Perform all experiments, data analysis and write the article. PY: set up duplex MSP experiment, CP: collecting and HPV analysis of CIN, SK, ST, PT, WT, DT and SN: collect clinical samples and data, AM: Hypothesize, design and analyze the experiments and write the article
The pre-publication history for this paper can be accessed here:
We would like to thank the entire staff of the Department of Obstetrics and Gynecology for their assistance in collecting and providing the tissue samples, Drs. Virote Sriuranpong and Gutkind JS, Kiat Ruxrungthum, and Mathurose Ponglikitmongkol for the CC cell lines, HeLa(S), HeLa(K) and SiHa, respectively, peripheral nerve research unit for assisting in microdissection and Dr. Virote Sriuranpong, Ms Petra Hirsch, Mrs. Nita Suyarnsestakorn and Asia Science Editing for language editing the manuscript. This work has been supported by the National Center for Biotechnology and Genetic Engineering (Thailand), The Royal Golden Jubilee Ph.D. program, the Thailand Research Funds and the Molecular Biology and Genetics of Cancer Development research unit, Chulalongkorn University.
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