CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
October 05, 2006 --
With the genomes of hundreds of organisms now catalogued, one of the
next major challenges is to identify proteins and their interactions.
The current issue of CSH Protocols, published online
(www.cshprotocols.org), features two freely available, cutting-edge
methods that address this challenge.
One of the freely accessible protocols, developed by Dr. Marian Walhout
and her colleagues at the University of Massachusetts Medical School,
describes a means for identifying protein-DNA interactions in complex
organisms. Her team has used this method to generate a protein-DNA
interaction network by characterizing the DNA sequences to which
proteins bind in the model organism C. elegans (the "worm" used in many
developmental studies). Because it relies on basic molecular biology
techniques, this method will also be useful for analyzing the
intricately coordinated patterns of gene regulation in other species.
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