Some precancerous lesions such as Barrett's epithelium and many cancers are resistant to apoptosis and therefore might be uniquely suited for treatment by CSA. This case report describes the first use of CSA in a patient with recurrent SCCA for palliative treatment that has resulted in complete remission for 2 years. Further investigation using CSA as a palliative measure for esophageal cancer should be considered.
Competing interests
Dr. Brooks Cash: declares no competing interests
Dr. Mark Johnston: invented the CSA devices but has permanently divested himself of all financial interests and potential future royalties to an U.S.A. Internal Revenue Service approved 501c3 charity. Dr. Johnston has served as a consultant to CSA Medical Inc. the developer of the cryospray ablation device.
Lavonne Johnston, PA-C has been salaried as a research assistant funded through CSA Medical Inc.
Authors' contributions
BC contributed to the editing of this manuscript and participated in the care of the case described.
MJ contributed to the editing of this manuscript and participated in the care of the case described.
LJ, PA-C contributed to the writing and editing of the submitted manuscript and has been the primary research assistant for this cryotherapy research.
Acknowledgements
We would like to thank Jennifer Cartledge the engineer who co-invented this device with Dr. Johnston who has made innumerable refinements to make this device and technique a safe and very promising palliative modality for esophageal cancer.
We would like to thank Jacinda Foggy the CSA Medical technician who has helped with virtually all procedures performed and has helped manage much of the clinical data.
We would like to thank CSA Medical Inc. who supplied the cryospray ablation (CSA) device to the National Naval Medical Center under a Cooperative Research And Development Agreement (CRADA).
Since this was a single case Humanitarian Use Device Exemption Study no funding was sought by the investigators or the institution. The written permission was obtained from the patient for publication of this study, the study was approved by the Institutional review board and permission from US FDA was obtained.
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