The purpose of this paper is to put forth the notion that …

• Abstract
• Background
• Regenerative cells in cord blood
• Cord blood transplantation without host preconditioning: will there be GVHD?
• Will the graft be cleared?
• Strategies for clinical implementation
• Conclusion
• References
• Table

Biology Articles » Immunobiology » Cord blood in regenerative medicine: do we need immune suppression? » Conclusion

Conclusion

- Cord blood in regenerative medicine: do we need immune suppression?

In summary, the authors propose that expanding the use of cord blood to non-preconditioned adult recipients for regenerative purposes would be a great step for the practical advancement of stem cell therapeutics. By overcoming allogeneic barriers in regenerative medicine, the fundamental limitations of autologous cell therapy may result in effective standardized "off-the-shelf" cellular products for regenerative therapeutics. This major step can only be performed by understanding the unique immunology of cord blood grafts, leveraging the graft's regenerative capability for specific indications, and identifying methods of amplifying cellular effects through administration of various drugs.