Tables

- Computer simulation analysis of normal and abnormal development of the mammalian diaphragm

Table 1

Cellular calculus within Nudge++™
*Internal States*	+	*External Cues*	→	*Cell Actions*

age		boundaries		growth
cell-cycle phase		local position		division
phase-age		global position		movement
generation				death
clone
lineage
Individual model cells evaluate internal states and environmental cues and carry out specific actions based on this evaluation. Additional states, cues and actions other than those listed can be added to each column. A cohort of model cells forms a tissue or organ. Simulations represent the pooled behavior of these cell cohorts over simulated tissue time. Details of these procedures have been presented elsewhere[16].
Fisher et al. Theoretical Biology and Medical Modelling 2006 3:9 doi:10.1186/1742-4682-3-9

Table 2

Sequential achievement of modeling goals
	Simulation I	Simulation II	Simulation III	Simulation IV	Simulation V

	Homogeneous Growth	Edge Growth	Edge Growth with Chest Wall Trophism	Edge Growth with Chest Wall Trophism and Tropism	Edge Growth with Chest Wall Trophism and Differential Tropism

Development from PPF alone	+	+	+	+	+

Non-muscular central tendon	+	+	+	+	+

Central before peripheral differentiation		+	+	+	+

Anterior extension along body wall			+/-	+	+

Curvilinear morphology of hemidiaphragm				+	+

Normal anterior diaphragm ipsilateral to CDH				+/-	+

Posterior PPF persists as large CDH					+
The success of individual simulations in reproducing major observed morphological components of the developing normal and CDH diaphragm are tabulated; (+), component present; (+/-), component partially present.
Fisher et al. Theoretical Biology and Medical Modelling 2006 3:9 doi:10.1186/1742-4682-3-9

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