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An increasingly common application of gene expression profile data is the reverse …


Biology Articles » Bioengineering » Comparative analysis of microarray normalization procedures: effects on reverse engineering gene networks » Table 1

Table 1
- Comparative analysis of microarray normalization procedures: effects on reverse engineering gene networks

Summary of four commonly used normalization procedures
Procedure Background correction Normalization Summarization Reference

MAS5 Ideal (full or partial) MM subtraction Constant Tukey biweight Hubbell et al., 2002
RMA Signal (exponential) and noise (normal) close-form transformation Quantile Median polish Irizarry et al., 2003
GCRMA Optical noise, probe affinity and MM adjustment Quantile Median polish Wu et al., 2004
Li–Wong None Invariant set Multiplicative model fitting Li and Wong, 2001

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