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- Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure

Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
Ken Donaldson, 1 Lang Tran,2 Luis Albert Jimenez,1 Rodger Duffin,1 David E Newby,3 Nicholas Mills,3 William MacNee,1 and Vicki Stone4
1ELEGI Colt Laboratory, Queens Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
2Institute of Occupational Medicine, Research Park North, Riccarton, Edinburgh EH14 4AP, UK
3Cardiovascular Research, Division of Medical and Radiological Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SU, UK
4Napier University, School of Life Sciences, 10 Colinton Rd, Edinburgh EH10 5DT, UK
Ken Donaldson: ken.donaldson@ed.ac.uk ; Lang Tran: Lang.Tran@iomhq.org.uk ; Luis Albert Jimenez: a.jimenez@ed.ac.uk ; Rodger Duffin: Rodger.Duffin@ed.ac.uk ; David E Newby: d.e.newby@ed.ac.uk ; Nicholas Mills: Nick.Mills@ed.ac.uk ; William MacNee: wmacnee@ed.ac.uk ; Vicki Stone: v.stone@napier.ac.uk
This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the lungs through their potential to cause oxidative stress, inflammation and cancer; they also have the potential to redistribute to other organs following pulmonary deposition. These different CDNP show considerable heterogeneity in composition and solubility, meaning that oxidative stress may originate from different components depending on the particle under consideration. Key CDNP-associated properties of large surface area and the presence of metals and organics all have the potential to produce oxidative stress. CDNP may also exert genotoxic effects, depending on their composition. CDNP and their components also have the potential to translocate to the brain and also the blood, and thereby reach other targets such as the cardiovascular system, spleen and liver. CDNP therefore can be seen as a group of particulate toxins unified by a common mechanism of injury and properties of translocation which have the potential to mediate a range of adverse effects in the lungs and other organs and warrant further research.

Part Fibre Toxicol. 2005; 2: 10. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

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