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In here the authors described a new class of PPAR agonists, the 5…


Biology Articles » Biochemistry » A New Class of Peroxisome Proliferator-activated Receptor Agonists with a Novel Binding Epitope Shows Antidiabetic Effects* » Table

Table
- A New Class of Peroxisome Proliferator-activated Receptor Agonists with a Novel Binding Epitope Shows Antidiabetic Effects*

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  TABLE I. Crystallographic data




PPARγ -LBD-BVT.13 complex

PPARγ -LBD-BVT.762 complex

PPARγ -LBD-BVT.763 complex

Data collection      
Resolution (Å) 2.9 3.15 2.90
I/-sigma (in highest resolution shell) 13.4 (3.2) 20.3 (3.2) 33.3 (2.8)
Completeness (in highest shell) 86.9 (91.1) 89.0 (93.6) 94.4 (96.5)
Refinement      
Rsym (in highest shell)a 0.095 (0.400) 0.089 (0.314) 0.068 (0.333)
Rfactor 0.191 0.222 0.224
Rfree 0.295 0.308 0.292
Ramachandran angle distribution: core, allowed, generously allowed, disallowed (%)b

87.0, 12.2, 0.8, 0

83.9, 15.3, 0.8, 0

87.1, 12.5, 0.4, 0

a, where (I(h)i) is the average intensity of reflection h, Σh is the sum over all reflections, and Σi is the sum of all measurements of reflection h.

b Values and definitions are from Procheck (39).

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Source: J. Biol. Chem., Vol. 279, Issue 39, 41124-41130, September 24, 2004

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