We thank the research subjects, the nursing staff of the OregonHealth & Science University (OHSU) General Clinical ResearchCenter, Neil Cutler, Rick Boney, Krista Yuhas, Angie Koenig,Nancy Stahl, Brant Hasler, Rebecca Bernert, Cathy Evces, AnushaChhagan, Anju Bhargava, Dr. Les Christianson, Dr. Darian Minkunas,and Dr. Laurie Vessely. We also thank Dr. Keith Parrott, Pharm.D.,for preparation of the capsules and Enviro-Med for help in providingbright-light fixtures to the subjects following the study. Thiswork was supported by Public Health Service Grants R01 MH55703,R01 MH56874, R01 AG21826, and R01 HD42125 (to A.J.L.) and 5M01 RR000334 (to the General Clinical Research Center of OHSU).A.J.L. was supported by the National Alliance for Research onSchizophrenia and Depression 2000 Distinguished InvestigatorAward. J.S.E. was supported by Public Health Service Grant K23RR017636-01.
Abbreviations: SAD, seasonal affective disorder; PSH, phase-shift hypothesis; DLMO, dim light melatonin onset; PAD, phase angle difference; SIGH-SAD, Structured Interview Guide for the Hamilton Depression Rating Scale–SAD version
To whom correspondence should be addressed. E-mail: [email protected]
Freely available online through the PNAS open access option.
Author contributions: A.J.L. designed research; A.J.L. and V.K.B.performed research; A.J.L., B.J.L., J.S.E., and V.K.B. analyzeddata; and A.J.L., B.J.L., J.S.E., and V.K.B. wrote the paper.
Lewy, A. J., Lefler, B. J., Hasler, B. P., Bauer, V. K., Bernert,R. A. & Emens, J. S. (2003) Chronobiol. Int. 20, 1215–1217(abstr.).,
¶ Lewy, A. J., Lefler, B. J., Yuhas, K., Hasler, B. P., Bernert,R. A. & Emens, J. S. (2004) Neuropsychopharmacology 29,S103–S104 (abstr.).
|| Lewy, A. J., Emens, J. S., Lefler, B. J. & Bauer, V. K.(2005) Neuropsychopharmacology 30, S62–S63 (abstr.).
Conflict of interest statement: A.J.L. is coinventor on severalmelatonin use-patents owned by Oregon Health & Science Universitycurrently not licensed to any company.
© 2006 by The National Academy of Sciences of the USA