table of contents
a chemical genetic screen designed to address the mechanism of action of …
Biology Articles » Genetics » Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound » References
- Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound
- Minassian VA, Drutz HP, Al-Badr A (2003) Urinary incontinence as a worldwide problem. Int J Gynecol Obstet 82: 327–338.
- Cruz F (2004) Mechanisms involved in new therapies for overactive bladder. Urology 63: 65–73.
- Andersson KE (2004) New pharmacologic targets for the treatment of the overactive bladder: An update. Urology 63: 32–41.
- Nijman RJ (2004) Role of antimuscarinics in the treatment of nonneurogenic daytime urinary incontinence in children. Urology 63: 45–50.
- Chaliha C, Khullar V (2004) Mixed incontinence. Urology 63: 51–57.
- George SR, O'Dowd BF, Lee SP (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 1: 808–820.
- Howard AD, McAllister G, Feighner SD, Liu Q, Nargund RP, et al. (2001) Orphan G-protein-coupled receptors and natural ligand discovery. Trends Pharmacol Sci 22: 132–140.
- Wess J (1997) G-protein-coupled receptors: Molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB J 11: 346–354.
- Selbie LA, Hill SJ (1998) G protein-coupled-receptor cross-talk: The fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol Sci 19: 87–93.
- Penn RB, Pronin AN, Benovic JL (2000) Regulation of G protein-coupled receptor kinases. Trends Cardiovasc Med 10: 81–89.
- DiBello PR, Garrison TR, Apanovitch DM, Hoffman G, Shuey DJ, et al. (1998) Selective uncoupling of RGS action by a single point mutation in the G protein alpha-subunit. J Biol Chem 273: 5780–5784.
- Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (1998) RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells. J Neurochem 70: 1964–1972.
- Ishii M, Kurachi Y (2003) Physiological actions of regulators of G-protein signaling (RGS) proteins. Life Sci 74: 163–171.
- Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997) Regulators of G-protein signaling (RGS) proteins: Region-specific expression of nine subtypes in rat brain. J Neurosci 17: 8024–8037.
- Khawaja XZ, Liang JJ, Saugstad JA, Jones PG, Harnish S, et al. (1999) Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Galphaq proteins in the adult rat brain. J Neurochem 72: 174–184.
- Hewawasam P, Erway M, Thalody G, Weiner H, Boissard CG, et al. (2002) The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence. Bioorg Med Chem Lett 12: 1117–1120.
- Hajdu-Cronin YM, Chen WJ, Patikoglou G, Koelle MR, Sternberg PW (1999) Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: The RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity. Genes Dev 13: 1780–1793.
- Lee RY, Lobel L, Hengartner M, Horvitz HR, Avery L (1997) Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans. EMBO J 16: 6066–6076.
- Weinshenker D, Garriga G, Thomas JH (1995) Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans. J Neurosci 15: 6975–6985.
- Choy RK, Thomas JH (1999) Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. Mol Cell 4: 143–152.
- Kwok PY (2000) High-throughput genotyping assay approaches. Pharmacogenomics 1: 95–100.
- Kwok PY (2000) Approaches to allele frequency determination. Pharmacogenomics 1: 231–235.
- Brundage L, Avery L, Katz A, Kim UJ, Mendel JE, et al. (1996) Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability. Neuron 16: 999–1009.
- Patikoglou GA, Koelle MR (2002) An N-terminal region of Caenorhabditis elegans RGS proteins EGL-10 and EAT-16 directs inhibition of G(alpha)o versus G(alpha)q signaling. J Biol Chem 277: 47004–47013.
- Chase DL, Patikoglou GA, Koelle MR (2001) Two RGS proteins that inhibit Galpha(o) and Galpha(q) signaling in C. elegans neurons require a Gbeta(5)-like subunit for function. Curr Biol 11: 222–231.
- van Swinderen B, Metz LB, Shebester LD, Mendel JE, Sternberg PW, et al. (2001) Goalpha regulates volatile anesthetic action in Caenorhabditis elegans. Genetics 158: 643–655.
- Mendel JE, Korswagen HC, Liu KS, Hajdu-Cronin YM, Simon MI, et al. (1995) Participation of the protein Go in multiple aspects of behavior in C. elegans. Science 267: 1652–1655.
- Buckley NJ, Bonner TI, Buckley CM, Brann MR (1989) Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol 35: 469–476.
- Luthin GR, Wolfe BB (1984) Comparison of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding to muscarinic cholinergic receptors in rat brain. J Pharmacol Exp Ther 228: 648–655.
- Schoemaker H, Langer SZ (1985) [3H]diltiazem binding to calcium channel antagonists recognition sites in rat cerebral cortex. Eur J Pharmacol 111: 273–277.
- Ruat M, Traiffort E, Bouthenet ML, Schwartz JC, Hirschfeld J, et al. (1990) Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I]iodinated probes. Proc Natl Acad Sci U S A 87: 1658–1662.
- Zhou JY, Toth PT, Miller RJ (2003) Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: Gain of function of cyan fluorescent protein-tagged G gamma 3. J Pharmacol Exp Ther 305: 460–466.
- Klockner U, Trieschmann U, Isenberg G (1989) Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells. Arzneimittelforschung 39: 120–126.
- Moresco RM, Govoni S, Battaini F, Trivulzio S, Trabucchi M (1990) Omegaconotoxin binding decreases in aged rat brain. Neurobiol Aging 11: 433–436.
- Kaslow HR, Lim LK, Moss J, Lesikar DD (1987) Structure-activity analysis of the activation of pertussis toxin. Biochemistry 26: 123–127.
- Takasaki J, Saito T, Taniguchi M, Kawasaki T, Moritani Y, et al. (2004) A novel Galphaq/11-selective inhibitor. J Biol Chem 279: 47438–47445.
- Lan KL, Sarvazyan NA, Taussig R, Mackenzie RG, DiBello PR, et al. (1998) A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins. J Biol Chem 273: 12794–12797.
- Blinder D, Jenness DD (1989) Regulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae. Mol Cell Biol 9: 3720–3726.
- Dohlman HG, Song J, Ma D, Courchesne WE, Thorner J (1996) Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: Expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit). Mol Cell Biol 16: 5194–5209.
- Apanovitch DM, Slep KC, Sigler PB, Dohlman HG (1998) Sst2 is a GTPase-activating protein for Gpa1: Purification and characterization of a cognate RGS-Galpha protein pair in yeast. Biochemistry 37: 4815–4822.
- Leavitt LM, Macaluso CR, Kim KS, Martin NP, Dumont ME (1999) Dominant negative mutations in the alpha-factor receptor, a G protein-coupled receptor encoded by the STE2 gene of the yeast Saccharomyces cerevisiae. Mol Gen Genet 261: 917–932.
- Zhou J, Arora M, Stone DE (1999) The yeast pheromone–responsive G alpha protein stimulates recovery from chronic pheromone treatment by two mechanisms that are activated at distinct levels of stimulus. Cell Biochem Biophys 30: 193–212.
- Sikorski RS, Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19–27.
- Li E, Meldrum E, Stratton HF, Stone DE (1998) Substitutions in the pheromone-responsive Gbeta protein of Saccharomyces cerevisiae confer a defect in recovery from pheromone treatment. Genetics 148: 947–961.
- Stone DE, Reed SI (1990) G protein mutations that alter the pheromone response in Saccharomyces cerevisiae. Mol Cell Biol 10: 4439–4446.
- Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, et al. (1995) The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell 83: 1047–1058.
- De Backer MD, Gommeren W, Moereels H, Nobels G, Van Gompel P, et al. (1993) Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. Biochem Biophys Res Commun 197: 1601–1608.
- Lazareno S, Birdsall NJ (1993) Pharmacological characterization of acetylcholine-stimulated [35S]-GTP gamma S binding mediated by human muscarinic m1-m4 receptors: Antagonist studies. Br J Pharmacol 109: 1120–1127.
- Malkowicz SB, Wein AJ, Elbadawi A, Van Arsdalen K, Ruggieri MR, et al. (1986) Acute biochemical and functional alterations in the partially obstructed rabbit urinary bladder. J Urol 136: 1324–1329.
- Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71–94.
rating: 1.00 from 1 votes | updated on: 24 Jul 2007 | views: 10457 |