In this review, the authors examine the molecular and cellular events that …

• Abstract
• Introduction
• Pathology of gastric cancer
• Aetiology of gastric cancer
• The role of inflammation in gastric cancer
• Molecular mechanisms of gastric carcinogenesis
• Conclusion
• References

Biology Articles » Medicine » Pathobiology » Cellular and molecular aspects of gastric cancer » Conclusion

Conclusion

- Cellular and molecular aspects of gastric cancer

It is evident that gastric carcinoma results from a complex interaction between bacterial, environmental, host-genetic and molecular mechanisms. The importance of H pylori and the mechanisms by which the host recognises and responds to the bacterium are crucial in determining the resulting phenotype. Several common events are shared between the differing histological subtypes while distinct differences also highlight the fascinating divergence in histogenesis. The aetiology of these differences remains to be elucidated. Better understanding of these events will no doubt contribute significantly to our fight against this killer cancer. More importantly, the improved understanding of the pathogenesis of gastric cancer will serve as a paradigm for understanding other human cancers.