In this review, the authors discussed the advances in mapping and sequencing …

• Abstract
• Introduction
• Canine Genome Maps and Sequence
• The Canine Genome and Molecular Mechanisms of Disease
• The Canine System and Genetics of Complex Traits
• Phenotypic Variation in the Dog
• Population Structure and Linkage Disequilibrium in the Domestic Dog
• Conclusion
• References
• Figures

Biology Articles » Genetics » Genomics » Canine Genomics and Genetics: Running with the Pack » Introduction

Introduction

- Canine Genomics and Genetics: Running with the Pack

In July of 2004, the first high-quality draft (7.5×) sequence of the dog genome was made publicly available [1], providing an invaluable resource for navigating the genomes of more than 400 recognized dog breeds worldwide, as well as a number of closely related wild canids. This work represented the crowning achievement of the dog genomics community that has for years worked hard to demonstrate the utility of a mammalian genetic system outside of the commonly accepted rodent models [2–4]. In this review, we first briefly highlight some recent advances in our picture of the canine genome. With this background, we then focus on issues related to the identification of genes associated with complex traits, the dog as a model for advancement of human medical genetics, and the development of mapping tools that take advantage of features of population structure.