We thank Darien Whang, Michael Knittel, and Anna Bar for helpin human tissue sample collection; Mindy Hebert for discussions;Jason Casolari, Michael Clarke, and Catriona Jamieson for helpfuldiscussions and critical reading of the manuscript; and theStanford Histology Core Facility and the Stanford FunctionalGenomics Facility (Stanford University Medical Center). Thiswork was supported by National Cancer Institute Grant CA77097(to P.O.B.), National Institutes of Health Grants ARO46786 (toA.E.O.) and K08-AR0008 (to H.Y.C.), a National Science FoundationPredoctoral Fellowship (to J.B.S.), and the Howard Hughes MedicalInstitute. H.Y.C. is a Damon Runyon Cancer Research Foundationscholar. P.O.B. is an Investigator of the Howard Hughes MedicalInstitute.
Abbreviations: BCC, basal cell carcinoma; BMP, bone morphogenetic protein; ISH, in situ hybridization; IHC, immunohistochemistry.
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Freely available online through the PNAS open access option.
Author contributions: A.E.O. and P.O.B. contributed equallyto this work; J.B.S., A.E.O., and P.O.B. designed research;J.B.S., H.H.Z., K.M., and A.D.T. performed research; J.B.S.,H.H.Z., K.M., M.v.d.R., A.D.T., H.G., H.Y.C., G.S.M., and A.E.O.contributed new reagents/analytic tools; J.B.S., M.v.d.R., A.D.T.,R.W., A.E.O., and P.O.B. analyzed data; and J.B.S. and P.O.B.wrote the paper.
The authors declare no conflict of interest.
Data deposition: The array data reported in this paper havebeen deposited in the Gene Expression Omnibus (GEO) database,www.ncbi.nlm.nih.gov/geo (accession no. GSE5502).
© 2006 by The National Academy of Sciences of the USA