There are numerous biomaterials platforms that have been used for decades for the controlled delivery of drugs including cancer chemotherapies, birth control, insulin, anti-viral agents, analgesics, antibiotics, and cosmetics.
Journals such as the Journal of Biomedical Materials Research, Biomaterials, and Journal of Controlled Release have been filled for decades with the scientific advances in controlled-therapy release. Many of these publications deal with oral biomaterials and oral hygiene but have unfortunately escaped the attention of most dental professionals.
Regrettably, due to page limits, this paper cannot possibly review even a fraction of the drug delivery systems available. The reader is directed to several reviews on this topic [4-9]. Here we will discuss the various types of controlled-release systems available (passive versus controlled or activated) and enumerate the possible agents that could be released to control dental caries.