Login

Join for Free!
114081 members
table of contents table of contents

Biology Articles » Bioinformatics » Bioinformatics in microbial biotechnology – a mini review » Phenotype similarity and automated pathway comparisons

Phenotype similarity and automated pathway comparisons
- Bioinformatics in microbial biotechnology – a mini review

The next level of study that the researchers have taken is to compare the similar pathways to understand the effect of insertion and deletion of genes in various microorganisms and to understand the evolution at pathway level [38]. To compare two pathways, the genes in the pathway are aligned as follows. Two pathways match completely if every protein in the first pathway (or a gene-group within a pathway) has a corresponding homologous gene in another pathway (or the gene-group within the pathway). There is a gap if a homologous gene is deleted (inserted), and there is a mismatch if the corresponding homologous genes have a low similarity score. Based upon this modeling, comparison of H. pylori and yeast has shown many similar pathways. More importantly, a quantification mechanism has been found to compare two pathways.


rating: 5.14 from 7 votes | updated on: 1 Dec 2007 | views: 12220 |

Rate article:







excellent!bad…