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Biology Articles » Anatomy & Physiology » Bile acid interactions with cholangiocytes » Gallbladder epithelial cells

Gallbladder epithelial cells
- Bile acid interactions with cholangiocytes

 
Gallbladder epithelial cells and cholangiocytes share a number of functions, however their primary role in the liver and their reaction to disease are quite different. Similar to cholangiocytes, gallbladder epithelial cells express ASBT, and taurocholate have been shown to increase intracellular calcium, activate chloride channels and stimulate mucin secretion[90]. In contrast, ursodeoxycholate, through a PKCalpha-dependent pathway inhibits gallbladder mucin production[90]. The authors proposed that ursodeoxycholate inhibition of gallbladder mucin could provide benefit to biliary disorders such as cystic fibrosis.

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