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Biology Articles » Microbiology » Microbial Genetics » New Way That Bacteria Evolve Into Something That Can Make You Sick
February 17, 2009 — Researchers of the Michael
G. DeGroote Institute for Infectious Disease Research have discovered a
new way that bacteria evolve into something that can make you sick.
The finding, published in the Feb. 16 issue of the Proceedings of the National Academy of Sciences, has implications for how scientists identify and assign risk to emerging diseases in the environment.
The researchers found that bacteria can develop into illness-causing
pathogens by rewiring regulatory DNA, the genetic material that
controls disease-causing genes in a body. Previously, disease evolution
was thought to occur mainly through the addition or deletion of genes.
Brian Coombes, an assistant professor in the Department of
Biochemistry and Biomedical Sciences, was the lead investigator of the
study which involved researchers at McMaster University, the University
of Melbourne, Australia and the University of Illinois at Chicago, USA.
"Bacterial cells contain about 5,000 different genes, but only a
fraction of them are used at any given time," Coombes said. "The
difference between being able to cause disease, or not cause disease,
lies in where, when and what genes in this collection are turned on.
We've discovered how bacteria evolve to turn on just the right
combination of genes in order to cause disease in a host. It's similar
to playing a musical instrument – you have to play the right keys in
the right order to make music."
With infectious diseases on the rise, the McMaster finding has
implications on how new pathogens are identified in the environment.
Scientists currently monitor the risk of new diseases by assessing the
gene content of bacteria found in water, food and animals.
"This opens up significant new challenges for us as we move forward
with this idea of assigning risk to new pathogens," Coombes said.
"Because now, we know it's not just gene content – it is gene content
plus regulation of those genes."
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