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The severe side effects of steroidal and non-steroidal anti-inflammatory drug evoked the …


Biology Articles » Botany » Anti-Inflammatory Activity of Piper nigrum, Linn and Ricinus communis, Linn. » Results and Discussion

Results and Discussion
- Anti-Inflammatory Activity of Piper nigrum, Linn and Ricinus communis, Linn.

Results: The extracts of fruits of Piper nigrum and roots of Ricinus communis showed significant reduction in rat paw edema volume at a dose of 150 mg/kg body weight which is comparable to standard drug aspirin.  Results are as shown in Table. Discussion: Indigenous drug system or Ayurveda can be source of variety of new drugs, which can provide relief from inflammation, but their claimed reputation has to be verified on a scientific basis. In some cases indigenous drugs may be the only answer because these drugs have minimum side effects and are easily available at low cost.  Piper nigrum and Ricinus communis on preliminary phytochemical screening showed variety of constituents like sugar, amino acid, alkaloids, saponins, tannins and some phenolic compounds. The activity might be attributed to these components. 11, 12 TLC and HPTLC study of the extracts revealed more than 5 components at 254 nm and 365 nm. Acute toxicity showed that aqueous and non-aqueous extract of Piper nigrum was safe up to 1000 mg/kg body weight and aqueous and non-aqueous extract of Ricinus communis was safe up to 2000 mg/kg body weight.  From the results it can be observed that the pet ether extracts of the fruits Piper nigrum showed statistically significant anti-inflammatory activity at the p.o. dose level of 150 mg/kg body. The pet ether extract of roots of Ricinus communis showed moderate activity at the p.o.dose level of 150 mg/kg body weight in acute anti-inflammatory model.

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