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The severe side effects of steroidal and non-steroidal anti-inflammatory drug evoked the …


Biology Articles » Botany » Anti-Inflammatory Activity of Piper nigrum, Linn and Ricinus communis, Linn. » Introduction

Introduction
- Anti-Inflammatory Activity of Piper nigrum, Linn and Ricinus communis, Linn.

Inflammation is a normal protective response to tissue injury caused by physical trauma, noxious chemical or microbial agents. It is the body’s response to inactivate or destroy the invading organisms, to remove irritant and set the stage for tissue repair. It is triggered by the release of chemical mediators from injured tissue and migrating cell. 1, 2 Modern research in the field of anti- inflammatory drugs is directed towards developing potent anti- inflammatory compounds with improved tolerability and reduction in other major side effects. Drugs from plant origin are used in India for treatment of many diseases in traditional system of medicine 3. Black pepper consists of dried unripe fruits of Piper nigrum Linn. It is used to treat abnormal accumulation of liquid in cellular tissue, in kidney disease, diabetes, anemia, dysentery, laxative and softener of inflamed part 4. Castor oil is derived chiefly from the seed of Ricinus communis Linn.The better and pure quality of oil is administered in the form of emulsion with mucilage in inflammatory condition of bowels. The root of the plant is also useful in nervous disorder, rheumatic conditions such as lumbago, pleurodynia and sciatica5.  The purpose of this study was to evaluate anti- inflammatory potential of methanolic, ethanolic, chloroform, ethyl acetate and pet ether extract of fruits of Piper nigrum, Linn and roots of Ricinus communis, Linn.

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