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Aminoglycosides are a group of antibiotics that are effective against certain types …
Biology Articles » Molecular Biology » Aminoglycoside » Gentamicin
Gentamicin (also gentamycin) is an aminoglycoside antibiotic, and can treat many different types of bacterial infections, particularly Gram-negative infection. However, gentamicin is not used for Neisseria gonorrheae, Neisseria meningitidis or Legionella pneumophila infections.Gentamicin works by binding to a site on the bacterial ribosome, causing the genetic code to be misread.Like all aminoglycosides, when gentamicin is given orally, it is not effective. This is because it is absorbed from the small intestine, and then travels through the portal vein to the liver, where it is inactivated. Therefore, it can only be given intravenously, intramuscularly or topically.E. Coli has shown some resistance to gentamicin, despite being Gram-negative.
Side effectsGentamicin can cause deafness or a loss of equilibrioception in genetically susceptible individuals. These individuals have a normally harmless mutation in their DNA, that allows the gentamicin to affect their cells. The cells of the ear are particularly sensitive to this. It is sometimes used intentionally for this purpose in severe Ménière’s disease, to disable the vestibular apparatus.Gentamicin can also be highly nephrotoxic, particularly if multiple doses accumulate over a course of treatment. For this reason gentamicin is usually dosed by body weight. Various formulae exist for calculating gentamicin dosage. Also serum levels of gentamicin are monitored during treatment.
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