table of contents
Aminoglycosides are a group of antibiotics that are effective against certain types …
Biology Articles » Molecular Biology » Aminoglycoside » Apramycin
The novel aminoglycoside antibiotic apramycin is shown to be a potent inhibitor of protein synthesis in bacteria both in vivo and in vitro. In cell-free systems from Escherichia coli programmed with poly(U), apramycin induces translation errors, as assayed by incorporation of leucine, isoleucine and serine, although this effect occurs only to a limited extent. Apramycin inhibits the translocation step of protein synthesis both in vivo, in protoplasts of Bacillus megaterium, and in vitro, in cell-free systems from E. coli. It is proposed that this is the primary inhibitory effect of the drug.
rating: 3.78 from 27 votes | updated on: 24 Feb 2008 | views: 48475 |