|
Differentially expressed genes in GAN vs. normal fibroblasts as analyzed by oligonucleotide microarrays. Genes selected displayed at least a three-fold difference in expression level.
|
Name
|
Acc. number
|
Fold change
|
|
Genes involved in lipid metabolism and adipogensis
|
Complement component 3 precursor
|
NM_000064.1
|
33.67
|
Butyrylcholinesterase
|
NM_000055
|
20.67
|
Alpha-2,8-sialyltransferase
|
L32867.1
|
6.95
|
Fatty acid binding protein 5
|
NM_001444.1
|
6.48
|
ATP-binding cassette A6
|
AA099357
|
4.38
|
Meltrin alpha
|
W46291
|
5.51
|
Adipsin
|
NM_001928.1
|
-7.39
|
ATP-binding cassette B4
|
NM_000443.2
|
-9.77
|
Acyl coenzyme A:cholesterol acyltransferase
|
S73751.1
|
-24.91
|
Leptin
|
NM_000230.1
|
-34.35
|
|
|
|
Integral membrane proteins and receptors
|
GABA-B receptor
|
AF056085.1
|
8.85
|
Integrin, beta 3
|
M35999.1
|
4.89
|
GABA-B receptor R2
|
AF095784.1
|
5.05
|
GABA-B receptor splice variant 1
|
AF095723.1
|
6.06
|
Orphan G protein-coupled receptor
|
AF069755.1
|
4.52
|
Integral membrane serine protease
|
U76833.1
|
4.63
|
Hyaluronan-mediated motility receptor
|
NM_012485.1
|
3.14
|
Death receptor 6
|
BE568134
|
-4.14
|
Endothelin receptor
|
M74921.1
|
-5.12
|
P-glycoprotein (mdr1)
|
AF016535.1
|
-7.95
|
Membrane glycoprotein M6
|
D49958.1
|
-5.82
|
C18ORF1
|
NM_004338.1
|
-4.19
|
Glycoprotein M6A
|
BF939489
|
-6.68
|
Potassium channel beta subunit
|
L39833.1
|
-5.44
|
Endothelin receptor type B
|
NM_003991.1
|
-8.89
|
Potassium channel beta 1a subunit
|
U33428.1
|
-3.99
|
E-cadherin
|
NM_004360.1
|
-7.04
|
|
|
|
Cell division/proliferation/apoptosis
|
Survivin
|
NM_001168.1
|
6.37
|
PDZ-binding kinase
|
NM_018492.1
|
4.38
|
Survivin-beta
|
AB028869.1
|
6.53
|
Mitosin (CENPF)
|
NM_005196.1
|
3.79
|
Dickkopf homolog 1
|
NM_012242.1
|
4.59
|
Kinetochore associated 2
|
NM_006101.1
|
3.51
|
Cell division cycle 2
|
AL524035
|
3.47
|
WNT4
|
NM_030761.1
|
-4.05
|
Fritz
|
U91903.1
|
-4.83
|
Tumor necrosis factor-related protein
|
NM_030945.1
|
-6.03
|
EGF-like-domain, multiple 6
|
NM_015507.2
|
-8.22
|
|
|
|
Transcription factors and nuclear proteins
|
Transcription factor AP-2 alpha
|
BF343007
|
7.41
|
High mobility group AT-hook 1
|
NM_002131.1
|
5.58
|
Nuclear factor IB
|
AI700518
|
4.49
|
Interferon-inducible protein p78
|
NM_002462.2
|
7.57
|
|
|
|
Cytoskeleton
|
Rabkinesin6
|
NM_005733.1
|
4.66
|
Stathmin-like 2
|
NM_007029.1
|
-5.32
|
|
|
|
Pregnancy specific beta-1-glycoprotein
|
Pregnancy specific beta-1-glycoprotein 7
|
NM_002783.1
|
-5.85
|
Pregnancy specific beta-1-glycoprotein 4
|
NM_002780.1
|
-17.82
|
Pregnancy specific beta-1-glycoprotein 1
|
NM_006905.1
|
-62.90
|
|
|
|
Uncharacterized genes
|
Hypothetical protein PRO02730
|
AL137654
|
10.56
|
Uncharacterized bone marrow protein
|
NM_018454.1
|
5.06
|
Hypothetical protein FLJ10517
|
NM_018123.1
|
5.74
|
KIAA0101 gene product
|
NM_014736.1
|
5.10
|
KIAA0008 gene product
|
NM_014750.1
|
4.62
|
Doublecortin and CaM kinase-like 1
|
NM_004734.1
|
4.53
|
KIAA1547 gene product
|
AW873621
|
3.96
|
Hypothetical protein DKFZp762E1312
|
NM_018410.1
|
4.54
|
Hypothetical protein FLJ10829
|
NM_018234.1
|
5.12
|
Clone HQ0310 PRO0310p1
|
NM_016359.1
|
4.38
|
Hypothetical protein DKFZp564H1916
|
AI186739
|
3.69
|
KIAA0042 gene product
|
NM_014875.1
|
4.96
|
Hypothetical protein FLJ22009
|
NM_024745.1
|
4.11
|
Hypothetical protein FLJ23468
|
NM_024629.1
|
3.48
|
Hypothetical protein DKFZp564N1116
|
BF344237
|
4.03
|
Hypothetical protein FLJ10781
|
NM_018215.1
|
-3.68
|
Myomegalin
|
AB042557.1
|
-4.97
|
Hypothetical protein DKFZp564B052
|
NM_030820.1
|
-5.46
|
KIAA0008 gene product
|
AK002054.1
|
-16.44
|
MGC:3052
|
BC002449.1
|
-7.73
|
KIAA0865 gene product
|
AI522028
|
-7.70
|
|
|
|
Miscellaneous
|
Matrix metalloproteinase 1
|
NM_002421.2
|
7.73
|
Carbonic anhydrase XII
|
NM_001218.2
|
7.80
|
Topoisomerase II alpha
|
AU159942
|
6.87
|
Step II splicing factor SLU7
|
AV733266
|
6.93
|
Monocyte chemotactic protein
|
S69738.1
|
4.37
|
Ribonucleotide reductase M2
|
BE966236
|
4.59
|
Plasminogen activator, urokinase
|
NM_002658.1
|
4.19
|
Cathepsin C
|
NM_001814.1
|
4.34
|
Atrophin-1 interacting protein 1
|
NM_012301.1
|
-3.89
|
Monoamine oxidase A
|
AA923354
|
-4.77
|
Type II iodothyronine deiodinase
|
U53506.1
|
-2.80
|
Phosphatidylserine-binding protein
|
NM_004657.1
|
-3.98
|
Scrapie responsive protein 1
|
NM_007281.1
|
-5.72
|
Natural killer cell transcript 4
|
NM_004221.1
|
-5.94
|
CD24 signal transducer
|
L33930
|
-9.16
|
Elastase 2
|
NM_001972.1
|
-9.71
|
CD24 antigen
|
AA761181
|
-19.19
|
|
|
Answers to all your Biology Questions
