C.L. – conceived of the study; performed the cell transfections and immunohistochemsitry; supervised the entire project; drafted the manuscript.
Y.P. – performed the microarray analyses; participated in experimental design.
S.C. – performed the quantitative RT-PCR; participated in data analysis.
D.G. – drafted the manuscript; participated in data analysis and sequence alignment.
R.L. – designed the experimental strategy; carried out data analysis; finalized the manuscript.
All authors have read and approved of the final version of this manuscript.
We are grateful to Gee Ying Ching for helpful discussions and advice. This work was supported by National Institutes of Health grants P50 AG08702 for C.L.L. and NIH15182 for R.K.H.L.