..................................................
Table 1: Characteristics of study subjects and group averages of lung function parameters over the survey periods
|
|
|
|
Panel
|
|
|
|
|
|
COPD
|
Asthma
|
IHD
|
|
|
Variable (unit)
|
Gender
|
Obs
|
Mean
|
SD
|
Obs
|
Mean
|
SD
|
Obs
|
Mean
|
SD
|
|
Age (years)
|
Male
|
7
|
67
|
11
|
5
|
33
|
15
|
6
|
63
|
11
|
|
Female
|
4
|
65
|
7
|
6
|
48
|
10
|
1
|
64
|
-
|
|
Total
|
11
|
67
|
9.1
|
11
|
41
|
14
|
7
|
64
|
10
|
BMI (kg/m2)
|
Male
|
7
|
27
|
6
|
5
|
25
|
4
|
6
|
26
|
3
|
|
Female
|
4
|
25
|
3
|
6
|
23
|
3
|
1
|
29
|
-
|
|
Total
|
11
|
26
|
5
|
11
|
24
|
3
|
7
|
26
|
3
|
FVC (% predicted)
|
Male
|
108
|
63
|
10
|
38
|
113
|
11
|
139
|
81
|
10
|
|
Female
|
63
|
61
|
9
|
70
|
116
|
12
|
31
|
80
|
4
|
|
Total
|
171
|
63
|
10
|
108
|
115
|
12
|
170
|
81
|
9
|
FEV1 (% predicted)
|
Male
|
108
|
45
|
10
|
38
|
94
|
13
|
139
|
84
|
10
|
|
Female
|
63
|
47
|
10
|
70
|
96
|
18
|
31
|
84
|
5
|
|
Total
|
171
|
45
|
10
|
108
|
95
|
16
|
170
|
84
|
10
|
NO in exhaled breath (ppb)
|
Male
|
|
|
|
37
|
66
|
40
|
|
|
|
|
Female
|
|
|
|
70
|
42
|
27
|
|
|
|
|
Total
|
|
|
|
107
|
50
|
34
|
|
|
|
|
..................................................
Table 2: Concentrations of PM, metals from PM2.5, gaseous pollutants, and climatic conditions (1999 spring and winter)
|
|
Variable
|
Unit
|
Spring
|
Winter
|
Overall
|
|
|
|
|
|
Obs
|
Mean
|
SD
|
GMean
|
IQR
|
Obs
|
Mean
|
SD
|
GMean
|
IQR
|
Mean
|
SD
|
GMean
|
Min
|
Max
|
IQR
|
|
PM2.5*
|
μg/m3
|
32
|
18.2
|
5.0
|
17.4
|
8.1
|
30
|
36.7
|
24.1
|
27.8
|
40.9
|
27.2
|
19.4
|
21.8
|
4.5
|
100
|
22.7
|
PM10–2.5 *
|
μg/m3
|
32
|
18.7
|
7.4
|
17.4
|
9.0
|
30
|
12.3
|
5.4
|
11.0
|
8.3
|
15.6
|
7.2
|
14.0
|
3.4
|
39.6
|
7.1
|
PM10 *
|
μg/m3
|
32
|
36.9
|
10.8
|
35.4
|
13.1
|
30
|
49.0
|
28.1
|
40.2
|
45.3
|
42.8
|
21.8
|
37.6
|
7.9
|
123
|
26.9
|
Cd
|
ng/m3
|
30
|
0.29
|
0.09
|
0.27
|
0.14
|
30
|
0.63
|
0.50
|
0.47
|
0.47
|
0.46
|
0.40
|
0.36
|
0.09
|
2.0
|
0.31
|
Cr
|
ng/m3
|
30
|
0.90
|
0.47
|
0.80
|
0.61
|
30
|
2.8
|
2.0
|
2.2
|
2.7
|
1.9
|
1.7
|
1.3
|
0.2
|
9.8
|
1.6
|
Fe
|
ng/m3
|
30
|
339
|
180
|
303
|
212
|
30
|
227
|
132
|
190
|
208
|
283
|
167
|
240
|
54.1
|
893
|
202
|
Ni
|
ng/m3
|
30
|
5.1
|
4.7
|
3.6
|
4.2
|
30
|
4.6
|
8.0
|
2.7
|
2.5
|
4.8
|
6.5
|
3.1
|
1.0
|
42.3
|
2.8
|
Pb
|
ng/m3
|
30
|
24.4
|
9.6
|
22.2
|
15.6
|
30
|
36.8
|
23.8
|
27.7
|
33.5
|
30.6
|
19.0
|
24.8
|
2.2
|
99.8
|
19.9
|
Pt
|
pg/m3
|
30
|
5.3
|
6.8
|
3.3
|
3.9
|
30
|
4.6
|
10.3
|
1.4
|
2.7
|
5.0
|
8.6
|
2.2
|
0.05
|
54.9
|
3.3
|
V
|
ng/m3
|
30
|
2.4
|
1.6
|
2.0
|
2.0
|
30
|
1.1
|
0.52
|
0.95
|
0.97
|
1.8
|
1.4
|
1.4
|
0.47
|
6.3
|
1.3
|
Zn
|
ng/m3
|
30
|
28.7
|
13.0
|
26.4
|
15.1
|
30
|
63.0
|
38.2
|
51.4
|
58.0
|
45.8
|
33.1
|
36.8
|
13.9
|
159
|
32.9
|
NO2 †
|
μg/m3
|
32
|
76.1
|
13.6
|
75.0
|
17.5
|
35
|
65.5
|
13.3
|
64.0
|
14.6
|
70.6
|
14.4
|
69.0
|
27.6
|
102
|
20.9
|
CO†
|
mg/m3
|
32
|
2.1
|
0.3
|
2.1
|
0.50
|
34
|
12.3
|
4.9
|
11.5
|
6.1
|
7.4
|
6.2
|
5.0
|
1.6
|
28.9
|
10.5
|
O3 ‡
|
μg/m3
|
32
|
70.9
|
12.5
|
69.8
|
16.9
|
34
|
16.0
|
8.1
|
14.3
|
10.0
|
42.6
|
29.5
|
30.8
|
6.6
|
95.3
|
58.7
|
SO2 ‡
|
μg/m3
|
32
|
4.7
|
1.8
|
4.3
|
2.5
|
35
|
7.9
|
2.2
|
7.6
|
3.9
|
6.4
|
2.6
|
5.8
|
1.2
|
11.6
|
4.0
|
T
|
°C
|
32
|
23.7
|
1.9
|
23.7
|
3.3
|
35
|
9.5
|
2.1
|
9.3
|
2.7
|
16.3
|
7.4
|
14.5
|
5.3
|
27.0
|
14.3
|
RelHum
|
%
|
32
|
46.5
|
10.2
|
45.4
|
14.0
|
35
|
66.7
|
13.5
|
65.1
|
14.0
|
57.0
|
15.7
|
54.8
|
29.0
|
87.0
|
24.0
|
BarP
|
mm Hg
|
32
|
762
|
2.6
|
762
|
3.4
|
35
|
762
|
7.3
|
762
|
12.1
|
762
|
5.5
|
762
|
748
|
773
|
6.6
|
PM2.5 Indoor§
|
μg/m3
|
28
|
24.7
|
7.8
|
23.7
|
9.0
|
31
|
27.0
|
12.0
|
24.4
|
18.8
|
25.9
|
10.2
|
24.1
|
10.2
|
56.5
|
14.4
|
|
*Averages of 24 h concentrations measured at 2 locations. †Averages of 24 h concentrations recorded at 5 fixed sites. ‡Averages of 24 h concentrations recorded at 2 fixed sites. §Averages of 24 h concentrations measured at 3 study participants' homes per season. |
..................................................
Table 3: Correlations among pollutants and weather variables
|
|
|
PM2.5
|
PM10–25
|
PM10
|
NO2
|
O3
|
CO
|
SO2
|
T
|
RelHum
|
BarP
|
|
PM2.5
|
1
|
|
|
|
|
|
|
|
|
|
PM10–25
|
0.34
|
1
|
|
|
|
|
|
|
|
|
PM10
|
0.93
|
0.61
|
1
|
|
|
|
|
|
|
|
NO2
|
0.43
|
0.51
|
0.45
|
1
|
|
|
|
|
|
|
O3
|
-0.51
|
0.31
|
-0.36
|
0.17
|
1
|
|
|
|
|
|
CO
|
0.67
|
-0.09
|
0.55
|
0.05
|
-0.87
|
1
|
|
|
|
|
SO2
|
0.34
|
-0.16
|
0.21
|
0.01
|
-0.61
|
0.65
|
1
|
|
|
|
T
|
-0.31
|
0.56
|
-0.10
|
0.36
|
0.79
|
-0.74
|
-0.56
|
1
|
|
|
RelHum
|
0.17
|
-0.37
|
0.06
|
-0.36
|
-0.62
|
0.54
|
0.43
|
-0.48
|
1
|
|
BarP
|
0.65
|
0.24
|
0.56
|
0.47
|
-0.15
|
0.28
|
0.18
|
-0.15
|
-0.17
|
1
|
|
Table 4
|
Variations in respiratory function per unit increase of air pollutant concentrations in the three panels
|
|
|
|
PM2.5
|
PM10–2.5
|
PM10
|
NO2
|
CO
|
O3
|
Pollutant increase
|
|
|
10 μg/m3
|
10 μg/m3
|
10 μg/m3
|
10 μg/m3
|
1 mg/m3
|
10 μg/m3
|
Panel
|
Outcome
|
Time
|
β *
|
SE (β)
|
p
|
β
|
SE (β)
|
p
|
β
|
SE (β)
|
p
|
β
|
SE (β)
|
p
|
β
|
SE (β)
|
p
|
β
|
SE (β)
|
p
|
|
COPD
|
|
24 h†
|
-0.80
|
0.36
|
0.027
|
-1.32
|
1.06
|
0.210
|
-0.66
|
0.30
|
0.027
|
-0.72
|
0.49
|
0.139
|
-0.14
|
0.15
|
0.353
|
0.01
|
0.57
|
0.983
|
|
FVC (%)
|
48 h‡
|
-0.89
|
0.41
|
0.031
|
-1.46
|
1.31
|
0.265
|
-0.75
|
0.35
|
0.032
|
-0.43
|
0.58
|
0.463
|
-0.13
|
0.18
|
0.497
|
0.18
|
0.65
|
0.783
|
|
|
72 h§
|
-1.10
|
0.55
|
0.044
|
-1.38
|
1.53
|
0.367
|
-0.94
|
0.47
|
0.045
|
-0.10
|
0.70
|
0.886
|
0.15
|
0.23
|
0.508
|
-0.03
|
0.86
|
0.977
|
|
|
24 h†
|
-0.47
|
0.33
|
0.149
|
-0.59
|
0.95
|
0.532
|
-0.37
|
0.27
|
0.167
|
-1.16
|
0.41
|
0.005
|
-0.05
|
0.13
|
0.725
|
-0.20
|
0.50
|
0.687
|
|
FEV1(%)
|
48 h‡
|
-0.69
|
0.37
|
0.061
|
-1.01
|
1.19
|
0.396
|
-0.58
|
0.31
|
0.067
|
-1.38
|
0.49
|
0.005
|
-0.12
|
0.16
|
0.467
|
0.31
|
0.56
|
0.578
|
|
|
72 h§
|
-1.06
|
0.50
|
0.032
|
-0.90
|
1.42
|
0.524
|
-0.87
|
0.43
|
0.040
|
-0.94
|
0.60
|
0.117
|
-0.03
|
0.20
|
0.900
|
0.68
|
0.74
|
0.363
|
Asthma
|
|
24 h†
|
-0.14
|
0.29
|
0.617
|
-0.17
|
0.75
|
0.822
|
-0.12
|
0.24
|
0.621
|
-0.53
|
0.31
|
0.081
|
0.02
|
0.12
|
0.842
|
-0.33
|
0.41
|
0.416
|
|
FVC (%)
|
48 h‡
|
-0.07
|
0.33
|
0.825
|
-0.36
|
0.91
|
0.695
|
-0.09
|
0.29
|
0.750
|
-0.59
|
0.32
|
0.065
|
-0.001
|
0.13
|
0.995
|
0.02
|
0.42
|
0.957
|
|
|
72 h§
|
-0.06
|
0.39
|
0.886
|
-0.24
|
1.07
|
0.824
|
-0.08
|
0.36
|
0.836
|
-0.54
|
0.37
|
0.149
|
-0.06
|
0.16
|
0.700
|
0.14
|
0.50
|
0.782
|
|
|
24 h†
|
-0.30
|
0.34
|
0.372
|
-0.67
|
0.89
|
0.448
|
-0.28
|
0.28
|
0.317
|
-1.10
|
0.35
|
0.002
|
-0.05
|
0.14
|
0.704
|
-0.41
|
0.50
|
0.421
|
|
FEV1(%)
|
48 h‡
|
-0.36
|
0.39
|
0.347
|
-1.19
|
1.07
|
0.265
|
-0.40
|
0.34
|
0.239
|
-1.28
|
0.37
|
0.001
|
-0.16
|
0.15
|
0.292
|
-0.01
|
0.51
|
0.983
|
|
|
72 h§
|
-0.40
|
0.46
|
0.384
|
-0.51
|
1.26
|
0.689
|
-0.40
|
0.43
|
0.351
|
-1.17
|
0.44
|
0.007
|
-0.28
|
0.18
|
0.126
|
0.46
|
0.60
|
0.449
|
IHD
|
|
24 h†
|
0.37
|
0.26
|
0.164
|
0.37
|
0.73
|
0.617
|
0.28
|
0.22
|
0.198
|
0.15
|
0.29
|
0.612
|
0.176
|
0.101
|
0.081
|
0.58
|
0.33
|
0.077
|
|
FVC (%)
|
48 h‡
|
0.51
|
0.29
|
0.082
|
-0.25
|
0.88
|
0.779
|
0.35
|
0.25
|
0.160
|
-0.06
|
0.37
|
0.868
|
0.132
|
0.120
|
0.271
|
0.36
|
0.42
|
0.392
|
|
|
72 h§
|
0.73
|
0.40
|
0.069
|
0.67
|
1.04
|
0.519
|
0.59
|
0.34
|
0.079
|
0.36
|
0.47
|
0.440
|
0.132
|
0.165
|
0.425
|
0.08
|
0.60
|
0.898
|
|
|
24 h†
|
0.43
|
0.33
|
0.192
|
0.25
|
0.86
|
0.770
|
0.32
|
0.27
|
0.240
|
-0.24
|
0.36
|
0.513
|
0.204
|
0.120
|
0.088
|
0.57
|
0.39
|
0.144
|
|
FEV1(%)
|
48 h‡
|
0.55
|
0.34
|
0.106
|
-0.23
|
1.02
|
0.818
|
0.38
|
0.29
|
0.193
|
0.00
|
0.44
|
0.994
|
0.114
|
0.142
|
0.420
|
0.53
|
0.50
|
0.288
|
|
|
72 h§
|
0.66
|
0.47
|
0.157
|
0.18
|
1.19
|
0.877
|
0.49
|
0.39
|
0.214
|
0.21
|
0.56
|
0.710
|
0.159
|
0.194
|
0.412
|
0.65
|
0.70
|
0.354
|
|
*Regression coefficient from GEE models for panel data controlling for repeated individual observations, temperature, relative humidity, and day of the week (COPD and IHD panels) or β-2 stimulant inhalation (asthma panel), representing the change in lung function index (% of predicted) per unit increase of pollutant concentration. †Concentration during the previous 24 hours. ‡Average concentration over the previous 48 hours. §Average concentration over the previous 72 h. |
..................................................
Source: Environ Health. 2006; 5: 11. © 2006 Lagorio et al; licensee BioMed Central Ltd.