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This work lays the foundation for developing a single Ad vector encoding …
An adenovirus prime/plasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes
The rAds constructed for this study.
rAd-mediated expression of rEDIII-4/2 protein as aGFP fusion.
Reactivity of immune sera towards monovalent and bivalent rEDIII proteins.
Simultaneous induction of antibodies that recognize and neutralize DEN virus serotypes 2 and 4.
Analysis of T cell responses elicited by the bivalent antigen.
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