Login

Join for Free!
118324 members
table of contents table of contents

This work lays the foundation for developing a single Ad vector encoding …


Biology Articles » Immunobiology » An adenovirus prime/plasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes » Conclusion

Conclusion
- An adenovirus prime/plasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes

Our data provide support for the hypothesis that a single vector system encoding a bivalent EDIII-based antigen has the capacity to induce a balanced immune response against both parental serotypes, thereby circumventing any potential possibility of immune interference. Thus, our data suggest that one can envisage the creation of a single antigen gene encoding EDIIIs of all four DEN virus serotypes, which could be incorporated into a single rAd vector to elicit a balanced tetravalent immune response. From a technical standpoint, it would be well within the capacity of the currently used first generation rAd vectors to accommodate the EDIIIs, but not the Es, of all four DEN virus serotypes. Prior immunity to Ad5, beyond a certain threshold, may compromise the efficacy of the Ad5 vector. Nevertheless, it has served, as a model to test our hypothesis, and it should be possible to switch to a vector with low/no seroprevalence such as Ad35, chimp Ad or adeno-associated virus in future.

rating: 0.00 from 0 votes | updated on: 20 Jul 2009 | views: 6256 |

Rate article:







excellent!bad…