Login

Join for Free!
116968 members
table of contents table of contents

Recurrent spontaneous abortion (RSA) is serious health problem affecting 2–5% of reproducing couples …


Biology Articles » Reproductive Biology » 1-alpha,25-dihydroxy-vitamin-D3 asnew immunotherapy in treatment ofrecurrent spontaneous abortion » Conclusion

Conclusion
- 1-alpha,25-dihydroxy-vitamin-D3 asnew immunotherapy in treatment ofrecurrent spontaneous abortion

Pregnancy is a complex integration of the body’s endocrine, neurological, anatomical and immunological systems as well as having significant influence from the environment. Immunological mechanisms of tolerance or intolerance to the placental unit are still only partially explored. The choice and designing of appropriate immunotherapeutic procedure in treating RSA may, therefore, pose a serious problem for practitioners. For the same reasons, different immunotherapies have been suggested for the immunological mechanisms involved in RSA and evidence from clinical trials has shown their relative success. VD3 is relatively new immunomodulatory agent with pleiotropic nature. Part of the immunomodulatory effects of VD3 is established on stimulation of Th2 immunity, suppression of MHC and co-stimulatory molecules expression, as well as Th2 cytokine promotion. Because RSA is Th1 phenomenon (in most cases), using of VD3 in prevention or treatment of RSA, or preeclamptic and eclamptic pregnancy may be very useful. To that effect, our first experiences are very encouraging.

rating: 2.80 from 5 votes | updated on: 1 Mar 2009 | views: 8554 |

Rate article:







excellent!bad…